Ceramides
We rebuild them with estolides.
The "mortar" between skin cells — replicated with plant-derived estolides that seal in moisture and strengthen the barrier.
Our Science
The barrier-first standard.
Trilipiderm was built on the Medasynnian Lipid Complex™ — our patented barrier-repair technology. It set a standard that now shapes every formula we make: barrier science, elevated by clinically studied actives dosed at levels that perform — to restore the barrier, sustain long-term skin health, and deliver results that last.
Barrier-First Formulation
Clinically Studied Actives
Actives At Studied Levels
Cruelty-Free & Vegan
One Pillar of the Standard
The Medasynnian Lipid Complex™
Our patented barrier-repair technology, engineered to rebuild the three lipids the skin barrier is made of.
Meadowfoam is the core, used in three forms — Seed Oil, Delta-Lactone, and Estolide. Each mirrors a lipid skin produces on its own, holding moisture for hours without an occlusive finish.
Around it, a quad-oil blend of sunflower, safflower, jojoba, and Abyssinian seed oils with olive-derived squalane and phytosterols — restoring the linoleic, oleic, and omega fatty acids skin loses with age.
The Complex is our foundation, not our finished formula. It restores the barrier; clinically studied actives do the rest.
Three Meadowfoam FormsQuad-Oil BlendSqualane & Phytosterols
Built Like the Barrier Itself
Your skin barrier is made of three lipids: ceramides, fatty acids, and cholesterol. As skin ages, it makes less of all three. The Medasynnian Lipid Complex™ rebuilds each one with a skin-identical, plant-derived match.
Fatty Acids
We supply them with Meadowfoam Delta-Lactone.
The skin's natural esters, thinning with age — restored by a rare meadowfoam ester that refines tone and texture.
Cholesterol
We mimic it with phytosterols.
Keeps the barrier flexible and calm — mimicked with sunflower and safflower phytosterols that soothe, hydrate, and regenerate.
Beyond the Complex
The actives we formulate with
Peptides, niacinamide, glutathione, tranexamic acid, retinol, vitamin C, hyaluronic acid, centella. Every one of them sits on the same barrier-repairing base.
Matrixyl 3000® Peptides
Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, studied in a blind, randomized, placebo-controlled split-face trial. Helps skin look firmer and improves the appearance of fine lines.
Niacinamide (Vitamin B3)
Brightens uneven tone, minimizes the appearance of pores, calms visible redness, and supports the skin's natural barrier with consistent use.
Glutathione & Stabilized Vitamin C
Ascorbic acid conjugated to gold to increase its bioavailability, with glutathione — a vitamin C precursor and antioxidant in its own right — replenishing ascorbic acid as it's broken down.
Tranexamic Acid
A brightening active with an unusually gentle tolerability profile. Helps visibly even skin tone and soften the look of dark spots and post-blemish marks over time.
Retinol & Hydroxypinacolone Retinoate
Phased across 1.5%, 3.5%, and 5.5% so skin acclimates instead of reacting — carried by dimethyl isosorbide and buffered with squalane and sodium hyaluronate.
Multi-Weight Hyaluronic Acid
High, mid, and low molecular weights hydrating at different depths — surface plumping, protection of the skin's natural moisturizing factor, and deeper hydration below it.
Centella Asiatica
The calming botanical behind madecassoside and asiaticoside. Soothes the look of redness and supports the skin's natural barrier, so stronger actives stay comfortable.
Coenzyme Q10 & Botanical Antioxidants
Ubiquinone alongside green tea, pomegranate, açaí, goji, and grape extracts to defend against the daily oxidative stress that accelerates visible ageing.
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Matrixyl 3000® reference: Fournial & Mondon, 2017 — a blind, randomized, placebo-controlled split-face study, n=28. We describe those outcomes qualitatively. Where we can't independently verify a percentage, we don't publish it.
Why It Matters
A barrier that works makes everything else work.
Skin's outermost layer is a lipid matrix — ceramides, cholesterol, and free fatty acids — that holds corneocytes in place and governs how fast water leaves the skin. Age, climate, over-cleansing, and over-exfoliation deplete it. A depleted matrix can't hold water, and it can't tolerate what you put on top of it.
That is where most actives fail. Retinol, exfoliating acids, and high-dose vitamin C on a depleted barrier sting and flush, and get abandoned before they can work. So repair isn't a separate step in our formulas — the lipids and the active are in the same bottle.
01
Moisture stays where it belongs
Replenished lipids slow water loss through the skin, so hydration holds for hours instead of minutes.
02
Actives are tolerated
A repaired barrier lets us formulate at levels that perform, without the stinging and flushing that make people quit.
03
Results compound
Skin that isn't in constant repair mode can spend its energy on the change you're actually after.
How We Formulate
Four rules we don't break.
The standard only means something if it survives contact with a formulation brief. This is how it does.
01
Start with the barrier
Every formula begins with its lipid base. If it can't hold moisture, the active sitting on top of it never gets a fair test.
02
Choose the active on evidence
We look for controlled human data on the exact molecule — not the ingredient family, and not the supplier's brochure.
03
Use a level that performs
An active listed at the very bottom of an ingredient panel is a marketing ingredient. We formulate at levels that match the research.
04
Say only what we can support
If we can't cite it, we don't claim it. Where the evidence is qualitative, so is our language.
